[Search] [Home] [About Us] [Why Bio-Center?] [Lab tests] [Order Test Kits] [Frequently Asked Questions] [Contact Us]

Fatty Acid

Profiles

Fatty Acid

  • Turn-around time = 7 to 10 days
  • Specimen is 1.0 mL of washed (EDTA) RBC's

Red blood cells are preferred over plasma or serum. RBCs have a long life and RBC membrane fatty acids are said to correspond closely with the fatty acids found in brain cells. Two fatty acids that the body cannot make are omega-6 polyunsaturated fatty acid, linoleic acid (LA), and omega-3 polyunsaturated fatty acid, alpha linolenic acid (ALA). The ratio of the omega-6 to omega-3 fatty acids in prehistoric times was about 1:1. By the year 1900, the ratio was around 4:1. Today, due to fast foods and the use of vegetable oils in cooking, the ratio is over 20:1.   A good ratio would be about 1.2 to 4.5.

Both LA and ALA are transformed into long chain polyunsaturated fatty acids 20 carbons or more in length. The 20-chain FA form eicosanoids which form prostaglandins or thromboxanes (via the cycloxygenase enzyme) or leukotrienes (via the lipoxygenase enzyme). If an imbalance occurs, excess prostaglandin E2, an inflammatory promoting compound, may be formed.

Some conditions associated with fatty acid imbalance are arthritis, skin problems, allergies, IBS, some autoimmune diseases, ADHD, depression, senile dementia, and aggressive behavior. An imbalance may also be seen in lactating or pregnant women.

The methodology is by gas chromatography. The accepted normal ranges established in our laboratory for RBC fatty acids are:

Omega-6
Linoleic acid (LA)90.0 to 182.0 uM/LEssential fatty acid
Gamma linolenic (GLA) 0.7 to 3.5 uM/LEicosanoid precursor
Dihomogammalinolenic acid (DGLA)11.0 to 31.0 uM/LEicosanoid substrate
Arachidonic acid90.0 to 250.0 uM/LEicosanoid substrate
Total Omega-6191.7 to 466.5 uM/L

Omega-3
Alpha linolenic acid (ALA) 0.5 to 2.9 uM/LEssential fatty acid
Eicosapentaenoic acid (EPA)4.0 to 20.0 uM/LEicosanoid substrate
Docosahexaenoic acid (DHA) 14.0 to 90.0 uM/LNeurological development
Total Omega-318.5 to 112.9 uM/L
Arachidonic acid to EPA ratio5.0 to 13.0 uM/L

Mononsaturated fatty acids
Oleic acid (OA)120.0 to 260.0 uM/L Membrane fluidity

Total monounsaturated fatty acids330 to 839 uM/L 

Saturated fatty acids
Palmitic acid210.0 to 370.0 uM/LHighly cholesterogenic
Stearic acid215.0 to 375.0 uM/LElevated triglycerides

Total Saturated fatty acids425.0 to 745.0 uM/L 

Unsaturated to saturated fatty acid ratio 0.78 to 1.13  

Trans fatty acids
Elaitic(C-18)2.0 to 10.0 uM/L 

Selected References:

  1. Nigel Plummer, Gastrointestinal Health, Essential Fatty Acids & Their Impact on the Immune System, Seroyal Workshop.
  2. Bralley, A., Lord, R. Laboratory Evaluations in Molecular Medicine: Nutrients, Toxicants, and Cell Regulators, IAMM, Norcross, GA., 2001: pp 134-173.
  3. Erasmus, U. Fats that Heal, Fats that Kill, 1986, Alive Books, Burnaby, BC Canada.

Back to Profiles Home Page


[Search] [Home] [About Us] [Why Bio-Center?] [Lab tests] [Order Test Kits] [FAQ] [Contact Us]
Back To Bio-Center Lab

This website is managed by The Center For The Improvement Of Human Functioning International
A Non-profit Medical, Research and Educational Organization
3100 North Hillside Avenue, Wichita, KS 67219 USA
Phone: 316-682-3100; Fax: 316-682-5054
© (CIHFI) 2008

This website and all contents are Copyright: 1997/2008 CIHFI - All Rights Reserved.