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Miscellaneous Tests

Miscellaneous Tests

Histamine
  • Turn-around time = 5 to 7 days
  • Specimen is whole blood drawn in a plain tube. Draw last if other tubes are collected. Do not allow blood to clot. Mix well and add 2 mL of whole blood to 5.0 mL of 10% trichloroacetic acid. Mix well and freeze.

Histamine is a reactive amine. Most histamine is found in platelets, tissue mast cells and basophils. Basophils are probably the source of most blood histamine. Histamine is a major neurotransmitter in the brain, especially in the hippocampus and throughout the autonomic nervous system. The measurement of blood histamine is important in studies of psychiatric, rheumatic, allergic and neurologic disorders. High blood histamine levels (histadelia) have been found in 20% of schizophrenics and other psychiatric disorders such as depression, "blank mind," obsessive-compulsive disorders and phobias. Low histamine levels (histapenia) is found in about 50% of schizophrenics and results in hyperactivity, mania, paranoia, hallucinations and "abnormal ideas."

Methodology for histamine is a fluorescent method following an ion-exchange separation technique.

The reference value established in our laboratory for histamine is 33 to 65 ng/mL.

Selected References:

  1. Jackson, J.A., Riordan, H.D., Neathery, S., Revard, C. Histamine levels in health and diseases. Jour OrthoMol Med. 1998. 13(4); pp236-240.
  2. Pfeiffer, C.C., Smyrl, E.G., Iliev. Extreme basophil counts and blood histamine levels in schizophrenic patients as compared to normals. Res Commun Chem Pathol Pharmacol, 1972a; 4:51.
  3. Schwartz, J.C. Histamine as a transmitter in brain. Life Sci, 1975; 17: 503-517.

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