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Miscellaneous Tests

Miscellaneous Tests

Carcinoembryonic Antigen (CEA)
  • Turn-around time = 5 to 7 days.
  • Specimen is serum.

CEA is a tumor associated antigen. It is present in embryonic tissues and certain epithelial cancers. CEA was first thought to be specific for digestive tract cancers, however, it may also be elevated in other malignancies and in some nonmalignant diseases. CEA is elevated in those who smoke; infections and bowel diseases, liver disease and non-colorectal cancers. A persistent elevation in circulating CEA following treatment is strongly indication of metastatic or residual disease.

Methodology is by Microparticle Enzyme Immunoassay (MEIA) technology.

The normal range establish in our laboratory is:
Nonsmoker= 0.0 to 3.0 ng/mL
Smokers= 0.0 to 5.0 ng/mL

Selected References:

  1. Krupely, J., Gold, P., Freedman, S.O. Demonstration of Tumor-Specific Antigen of Human Digestive System. J Exp Med 1968;183:387.
  2. Hansen, H.J., et al. Solving the Problem of Antibody Interference in Commercial "Sandwich"-Type Immunoassays of CEA. Clin Chem 1985;35:146.
  3. Martin, E.W., James, K.K., Hurtubise, P.E., et al.The Use of CEA as an Early Indicator for Gastrointestinal Tumor Recurrance and Second-Look Procedures, Cancer, 1977, 39(2):440-6.

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